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Prof. Dr. Per Berglund

Department of Industrial Biotechnology
KTH Royal Institute of Technology
AlbaNova, SE-106 91 Stockholm, Sweden

www.kth.se/profile/perbe

Prof. Dr. Per Berglund is PhD supervisor of ESR5 and Chair of Recruitment Committee. He is Professor of Biochemistry and deputy head of the department of Industrial Biotechnology at KTH Royal Institute of Technology, Stockholm, Sweden. Prof. Berglund’s research in the field of Biocatalysis uses tools and principles from Nature to provide bio-based environmentally smart production systems. His group combines enzymology, protein engineering, in silico molecular modelling and organic chemistry to tailor enzymes for industrial conditions and to develop multi-catalytic cascade reaction processes for sustainable synthesis of high-value chemical products. Prof. Berglund is teaching fundamental Biochemistry courses and the annual KTH Biocatalysis course on the Masters’ level.

Key Research Facilities, Infrastructure and Equipment
Fully equipped laboratories for molecular biology, enzyme expression and purification, organic synthesis and analysis.

Hosting University: KTH Royal Institute of Technology
Since its founding in 1827, KTH Royal Institute of Technology (KTH) in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. KTH is Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world dedicated to advancing knowledge. The five KTH campuses in Greater Stockholm, gather more than 13,000 full-time students, over 1,700 PhD students and approximately 3,700 full-time employees. KTH is working with industry and society in the pursuit of sustainable solutions to some of humanity’s greatest challenges. These are addressed with world leading, high-impact research and education in natural sciences and all branches of engineering, as well as in architecture, industrial management, urban planning, history and philosophy. Almost two-thirds of the SEK 4 billion turnover relates to research at KTH.

Relevant Publications and/or Research / Innovation Product

  1. H. Land, F. Ruggieri, A. Szekrenyi, W.-D. Fessner, P. Berglund. Engineering the Active Site of an (S)-Selective Amine Transaminase for Acceptance of Doubly Bulky Primary Amines. Adv. Synth. Catal. 2020, 362, 812-821. https://doi.org/10.1002/adsc.201901252
  2. F. Ruggieri, J. C. Campillo-Brocal, S. Chen, M. S. Humble, B. Walse, D. T. Logan, P. Berglund. Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase. Sci. Rep. 2019, 9, 16946. www.nature.com/articles/s41598-019-53177-3
  3. H. Land, J. C. Campillo-Brocal, M. S. Humble, P. Berglund. B‐factor Guided Proline Substitutions in Chromobacterium violaceum Amine Transaminase – An Evaluation of the Proline Rule as a Method for Enzyme Stabilization. ChemBioChem2019, 20, 1297-1304. https://doi.org/10.1002/cbic.201800749.
  4. L. Marx, N. Ríos-Lombardía, J. F. Farnberger, W. Kroutil, A. I. Benítez-Mateos, F. López-Gallego, F. Morís, J. González-Sabín, P. Berglund. Chemoenzymatic Approaches to the Synthesis of Cinacalcet. Adv. Synth. Catal. 2018, 360, 2157-2165. https://doi.org/10.1002/adsc.201701485
  5. F. Guo, P. Berglund. Transaminase Biocatalysis: Optimization and Application. Green Chem. 2017, 19, 333-360. http://dx.doi.org/10.1039/C6GC02328B
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